He is meeting on Friday with Turkey's foreign minister after talks with President Recep Tayyip Erdogan to try to bring Turkey into a consensus to prevent Syria from collapsing into wider turmoil. It's Blinken's 12th trip to the Mideast since the Israel-Hamas war erupted in Gaza last year but first since the ouster of Syrian President Bashar Assad.
The outgoing Biden administration is particularly concerned that a power vacuum in Syria could exacerbate already heightened tensions in the region and create conditions for the Islamic State group to regain territory and influence.
The fighting between Israel and Hamas has plunged Gaza into a severe humanitarian crisis. Israel's offensive has killed over 44,800 Palestinians in Gaza, more than half of them women and children, according to the Gaza Health Ministry, which does not say how many were combatants. The Israeli military says it has killed over 17,000 militants, without providing evidence.
"There's broad agreement on what we would like to see going forward, starting with the interim government in Syria, one that is inclusive and non-sectarian and one that protects the rights of minorities and women" and does not "pose any kind of threat to any of Syria's neighbors," Blinken said in joint statements with Turkish Foreign Minister Hakan Fidan
The insurgent groups that toppled Assad in Syria have not made clear their policy or stance on Israel, whose military in recent days has bombed sites all over the country, saying it is trying to prevent weapons from falling into extremist hands.
Blinken also said it was crucial to keep the Islamic State group under control.
"We also discussed the imperative of continuing the efforts to keep ISIS down. Our countries worked very hard and gave a lot over many years to ensure the elimination of the territorial caliphate of ISIS to ensure that that threat doesn't rear its head again," Blinken said.
The Turkish foreign minister said the two discussed ways of establishing prosperity in Syria and ending terrorism in the country.
"Our priority is establishing stability in Syria as soon as possible, preventing terrorism from gaining ground, and ensuring that IS and the PKK aren't dominant," Fidan said, in a reference to the banned Kurdistan Workers Party.
Blinken said: "We're very focused on Syria, very focused on the opportunity that now is before us and before the Syrian people to move from out from under the shackles of Bashar al-Assad to a different and better future for the Syrian people, one that the Syrian people decide for themselves."
Blinken and Fidan said they had also discussed a ceasefire for Gaza.
"We've seen in the last couple of weeks more encouraging signs that (a ceasefire) is possible," Blinken said.
Blinken, who is making his 12th trip to the Mideast since the Israel-Hamas war erupted last year but first since the weekend ouster of Assad, met with Turkish President Recep Tayyip Erdogan late Thursday.
The outgoing Biden administration is particularly concerned that a power vacuum in Syria could exacerbate already heightened tensions in the region, which is already wracked by multiple conflicts, and create conditions for the Islamic State group to regain territory and influence.