Jenna Ortega and Amy Adams are set to lead the cast of Klara and the Sun.
The duo are in negotiations to star in Taika Waititi's movie that is based on the New York Times best-selling novel by the Japanese-British author Kazuo Ishiguro.
The story follows Klara (Ortega), a robot girl designed to stop teenagers from getting lonely.
Klara is purchased by a mother (Adams) and a bright teen girl called Josie who loves her robot companion but is suffering from a mysterious illness. Klara attempts to save Josie and her loved ones from heartbreak and ends up discovering the power of human love in the process.
The book earned positive reviews following publication and was longlisted for the Booker Prize in 2021.
Dahvi Waller is adapting the script for the film and Ishiguro will serve as an executive producer on the project.
It is another big role for Jenna after her work in the likes of the Scream franchise and Wednesday, although she confessed that she "can't watch" herself on screen as she would spend too much time obsessing over things she disliked.
The 21-year-old star told Harper's Bazaar: "I can't watch my work, as I know I won't be able to push forward and continue to grow as an actor if I cling on to certain things.
"A lot of people in my profession can probably relate to this: when you do a take you don't like, you go to bed kicking yourself.
"But ultimately, all I can do is be vulnerable and honest when the camera's on, and then I have to move on and let it go."
Jenna is determined to be in control of her own career choices and hopes to make a "mistake" so she no longer has to worry about things going wrong.
She said: "I want to be able to really orchestrate my own future and make more specific, precise moves. I've even begged a little bit to be allowed to make a mistake. Because how can I learn if I don't do that for myself?
"I can't be scared of the fact that I might fall on my face. But it's hard to do that when so many people are watching."