The 39-year-old actress stars with the 44-year-old actor in new movie 'Fly Me To The Moon' and worked with his 35-year-old fiance in 2017's 'Rough Night', and she jokingly described them as "terrible unattractive".
She sarcastically told Entertainment Tonight: "They're just a terrible unattractive couple."
Revealing she had just been talking about how good looking the love birds are, she added: "I was like, 'This is the hottest couple I've ever seen.' It's absurd."
Beyond their looks, Scarlett - who is married to 'Saturday Night Live' head writer Colin Jost - also praised the couple for beauty "inside and out".
She said: "It's not hard to fall in love with Channing Tatum. He's just a wonderfully warm, charismatic person, and he's so professional. He's so kind, the crew loves him.
"He's like a total prankster and joker and, you know, loves to like pull your pigtails. He's just he's a joy to be around.
"[Zoe's] also a wonderful, real person and beautiful inside and out."
Channing and Zoe first met in 2021 on her feature film directorial debut 'Blink Twice', before getting engaged in October 2023 after two years together.
They rarely appear in public together or speak about their relationship, but in January 2023 he recalled being 'outed' by fans after following a number of fan accounts on Instagram.
He told Vanity Fair at the time: "I have no chill. I was just seeing what she was up to! Also, I didn't know anyone would know."
Channing also admitted he struggles with relationships because he worries about things falling apart and so he tries "too hard".
He explained: "Relationships are hard for me. Even though I am a bit of a monogamist. In business, I have no real fear of anything being destroyed.
"But heart things, when it comes to people I love, I have a really hard time. I end up trying too hard, you know?"
Zoe was previously married to Karl Glusman until they ended their romance after 18 months of marriage in 2021, while Channing was split from ex-wife Jenna Dewan - with whom he has daughter Everly, 10 - in 2019 after 10 years of marriage.